The purpose of this study was to develop and optimize oral delayed release formulation for Omeprazole. The drug loaded pellets were prepared by spaying Omeprazole suspension on the sugar spheres. These drug loaded pellets were coated with acid resistant polymer Hydroxypropylmethyl cellulose phalate-HP55 in a Wurster coater, to different polymer levels. The in vitro dissolution studies were conducted in 0.1N HCl for 2 hrs., followed by phosphate buffer pH 6.8, for 45 mins., with USP dissolution tester (type II).Enteric coated pellets with polymer load of 6.98 and 8.073% failed to provide required acid resistance to the pellets, but very insignificant amount of drug was leached from the coated pellets in the acid phase with polymer load 9.301 and 10.093%, whereas almost whole amount of drug was released in the buffer phase. The results generated showed the optimal % coating formulation with HPMC phthalate HP55 which is important in designing delayed release pellets dosage form, with acceptable dissolution profile.
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